They’ve discovered a far larger chunk of our genetic code is biologically active than previously thought.
The researchers hope the findings will lead to a deeper understanding of numerous diseases, which could lead to better treatments.
More than 400 scientists in 32 laboratories in the UK, US, Spain, Singapore and Japan were involved.
Their findings are published in 30 connected open-access papers appearing in three journals, Nature, Genome Biology and Genome Research.
The Encyclopedia of DNA Elements (Encode) was launched in 2003 with the goal of identifying all the functional elements within the human genome.
A pilot project looking at 1% of the genome was published in 2007.
Now the Encode project has analysed all three billion pairs of genetic code that make up our DNA.
They have found 80% of our genome is performing a specific function.